California governor signs bills to make textbooks lighter on wallets and backpacks

PARIS, Sept 28 (Reuters) - Clubs and players lashed out after the French government unveiled its 2013 budget on Friday, saying new tax plans would have a "disastrous effect" on domestic soccer. Tax hikes include a "temporary" 75 percent levy on annual earnings in excess of one million euros ($1.29 million) and a new rate of 45 percent on incomes above 150,000 euros. The existing rate is 40 percent on earnings above 69,505 euros. The government said the new "temporary" levy would be in operation until the country's debts were cleared. ...

Source: http://news.yahoo.com/blogs/technology-blog/california-governor-signs-bills-textbooks-lighter-wallets-backpacks-042327791.html

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Many GOP Operatives Conceding Ohio

September 29, 2012

Walter Shapiro: "Many of the well-known Ohio Republicans I interviewed offered their blunt assessments only after they were guaranteed complete anonymity. That is often the Faustian bargain of political journalism in 2012: robotic talking points on the record or something resembling honesty with no names attached. The reason, though, that I am emphasizing the don't-quote-me part of the equation is that I was stunned by the vehemence of the thumbs-down-on-Mitt verdict. All but conceding the state to Obama, these Republicans were offering what may be the biggest rejection of Ohio since Philip Roth wrote Goodbye Columbus."

Source: http://feedproxy.google.com/~r/PoliticalWire/~3/_7JqXLg3fEg/many_gop_operatives_conceding_ohio.html

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Donald Fehr, NHL Commissioner Bettman meet again

Matthew Schneider, left, special assistant to NHL Players Association executive director Donald Fehr, Winnipeg Jets' Ron Hainsey, center, and Steve Fehr, players union special counsel, arrive at NHL headquarters in New York, Friday, Sept. 28, 2012. With the clock ticking down to the start of the season, the NHL and its locked-out players are talking again. (AP Photo/ Louis Lanzano)

Matthew Schneider, left, special assistant to NHL Players Association executive director Donald Fehr, Winnipeg Jets' Ron Hainsey, center, and Steve Fehr, players union special counsel, arrive at NHL headquarters in New York, Friday, Sept. 28, 2012. With the clock ticking down to the start of the season, the NHL and its locked-out players are talking again. (AP Photo/ Louis Lanzano)

Winnipeg Jets' Ron Hainsey takes a break from a bargaining session at NHL headquarters in New York, Friday, Sept. 28, 2012. The NHL and the players' association agreed on issues related to player safety and drug testing Friday, but the core economic divide that is preventing an end to the league's latest lockout was not even on the agenda. (AP Photo/Louis Lanzano)

NHL players association general counsel Don Zavelo arrives at NHL headquarters in New York, Friday, Sept. 28, 2012. With the clock ticking down to the start of the season, the NHL and its locked-out players are talking again. (AP Photo/ Louis Lanzano)

Winnipeg Jets' Ron Hainsey, left, and Steve Fehr, players union special counsel, arrive at NHL headquarters in New York, Friday, Sept. 28, 2012. With the clock ticking down to the start of the season, the NHL and its locked-out players are talking again. (AP Photo/ Louis Lanzano)

New Jersey Devils goalie Johan Hedberg, of Sweden, arrives at NHL headquarters in New York, Friday, Sept. 28, 2012. With the clock ticking down to the start of the season, the NHL and its locked-out players are talking again. (AP Photo/ Louis Lanzano)

NEW YORK (AP) ? NHL Players' Association head Donald Fehr and NHL Commissioner Gary Bettman held a second round of private talks on Saturday in an effort to move closer to an agreement that would end the ongoing lockout.

While negotiating teams from the union and the league discussed definitions of what makes up hockey-related revenue ? the pool of money the sides are trying to figure out how to split up ? Fehr and Bettman talked about the differences that are keeping the sides apart.

"I spent a few minutes with Gary talking about the overall situation, and we agreed to keep in touch," Fehr said Saturday outside of the NHL's New York office. "I am sure we will talk again (Sunday). I don't know whether will meet again (Sunday). That remains to be seen.

"I am not going to talk about the specifics, but in general we're trying to discuss how do we find a way to make an agreement. How do we bridge the gap on the major issues that are between us."

The sides met for about four hours before finishing for the day. They agreed to meet again on Sunday.

They talked for a second straight day on matters separate from the core economic issues that ultimately will have to be hammered out. In the recently expired collective bargaining agreement between the league and the union, the players received a 57 percent share of hockey-related revenue.

The NHL wants to cut the number down to under 50 percent in the new deal. The league imposed a lockout on Sept. 16, when the previous agreement ran out, and the sides didn't meet again until Friday.

"Their position on the big stuff has been that a major move consists of changing the players' share from a reduction of 24 percent to 17 1/2 percent," Fehr said. "Our initial proposal made a move in their direction. We have amplified that by giving them several different ideas to consider about how to lengthen the agreement to how to be more in line with what they wanted."

Fehr said discussing what exactly makes up hockey-related revenue is significant, because that will determine how much money is there to be divided.

Some progress was made on Friday on secondary issues related to player safety and drug testing, areas that weren't expected to be contentious. The league and union held two sessions then that totaled about five hours and included an initial meeting between Bettman and Fehr.

"I wish we had spent (Friday) on what we consider to be the more meaningful issues, but it is what it is," NHL Deputy Commissioner Bill Daly said on Friday. "We really need to hear from the players' association on those. We need some kind of sign that they are prepared to compromise their economic position because we haven't had that since Aug. 14.

"We'll see if we get there."

At least they got back to talking ? which hadn't happened since a few days before the NHL locked out its players.

"It was a good day," Daly said. "We went through a lot of the areas we'd covered over the summer. We started closing off some agreements in some areas, and some continued areas of disagreements in others. It's part of the process."

All of the issues, big and small, must be ironed out before hockey can get out of the board room and back on the ice. So while the divisive topics still need to be tackled, the smaller ones have to be worked on, too.

"I don't want to use the adjective optimistic, but it was a productive discussion," NHL Players' Association special counsel Steve Fehr said on Friday. "We had a good session, and hopefully it will continue and build momentum."

The sides still aren't moving closer to a compromise while they talk about other issues.

And that is where the frustration lies. The NHL is waiting for the players' association to make a counterproposal to one the league made in the previous bargaining session more than two weeks ago.

"I don't think it's anybody's turn," Donald Fehr said Saturday. "If they have a good idea, I assume they will tell us. If we do, too, I certainly will not stand on ceremony."

But the NHL contends it has stated its position and needs the players' association to make what the league would consider a meaningful counter.

"We can't make them talk about what they don't want to talk about," Daly said. "In fairness, we do have to cover these issues if we're going to reach an agreement. What we're doing today is important, it's just not the most important things we can be doing.

"We've made at least two consecutive moves in significant dollars in their direction, and they haven't moved a single dollar in our direction since Aug. 4."

Former player Mathieu Schneider, now an NHLPA special assistant to the executive director, said Friday morning that there were agreements on more rigorous drug testing, expanding it to parts of the year during which testing is not currently done.

Neither side sees the use of performance-enhancing drugs as a problem in the NHL.

"We're in agreement that it's not an issue in our sport," Schneider said. "I think it's in the players' best interest as well as the sport to close off any possible time during the year where players could use."

Monetary issues are not expected to come up for discussion in this round of talks. Neither side has indicated it is prepared to make a new offer now regarding how to split up the more than $3 billion annual pot of hockey-related revenue.

"In general, when you're dealing with collective bargaining, when you start to have agreements on smaller issues, it can lead to bigger issues," Schneider said, "but it's still too early to say."

Saturday's talks came two days after the league canceled the remaining preseason games. The regular season is scheduled to start on Oct. 11.

If a deal isn't reached soon, regular-season games will be in danger of being lost. The NHL canceled the entire 2004-05 season because of a lockout that eventually led to the collective bargaining agreement that expired this month.

"The calendar continues to tick along," Daly said. "My guess is as time goes on, regular-season games are at risk. I don't think it can be any more urgent than where we are now. We've had that level of urgency for a long time. In some respects you can meet all you want, but if there is no compromise or no movement or no new proposals I am not sure at the end of the day what you're meeting over.

"There is a very high degree of urgency certainly on our side. I can't speak for their side, but I am sure they would tell you there is a degree of urgency there, too."

Steve Fehr contended that the players' association is willing to discuss any issues at any time to try to make a deal soon.

"We can discuss the core issues whenever they want to do it," he said. "Bargaining is not ping pong. There are no rules on who has to serve."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2012-09-29-HKN-NHL-Labor/id-8c9c068dbada42ffb9e5eaae4cbe6bee

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U.S., Gulf countries seek to advance missile defense plan

NEW YORK (Reuters) - The United States and its Gulf partners are looking to deepen cooperation on missile defense as tensions rise with Iran, and announcements could come soon on new purchases, U.S. officials said on Friday.

Secretary of State Hillary Clinton met with Gulf Cooperation Council (GCC) officials in New York as Washington seeks to boost regional defenses against perceived Iranian threats.

"Our aim is to help our Gulf partners with their defense needs ... there is a missile threat that they face, we want to help them face that threat as best they can," one senior U.S. official said, previewing the meeting for reporters.

"We've had expressions of interest from our partners in the Gulf in additional missile defense capabilities," the official said. "We hope that we will be having announcements in the near future regarding those expressions of interest."

The official declined to provide specifics on the plans with the GCC, a political and economic alliance linking Saudi Arabia, Kuwait, the United Arab Emirates, Qatar, Bahrain and Oman.

But Lockheed Martin Corp, the Pentagon's top supplier by sales, received an initial $1.96 billion contract in December for two of its Terminal High-Altitude Area Defense (THAAD) weapon systems for the United Arab Emirates, the first foreign sale of the system.

Lockheed has said other GCC members, including Saudi Arabia, have expressed interest. Other leading missile-defense contractors include Boeing Co, Raytheon and Northrop Grumman Corp.

Friday's talks reflect the increased tempo of U.S. efforts to put pressure on Tehran, which the United States and its allies say is seeking nuclear weapons capability under the cover of a civil program. Iran denies this, but has been hit with a series of international sanctions over its nuclear work.

SECURITY UMBRELLA

The United States has been working with Gulf states on a bilateral basis, not as a group, to boost the range of radar coverage and related capabilities across the Gulf for the earliest possible defense against any missiles fired by Iran.

The Pentagon said Defense Secretary Leon Panetta, who had planned to attend Friday's meeting along with White House Security Adviser Tom Donilon, was unable to make it due to bad weather in New York.

U.S. officials said the ultimate goal is a regional shield that can be coordinated with U.S. systems - parallel with Washington's drive to expand missile defense to protect NATO's European territory against ballistic missiles that could be fired by Iran.

The officials said expanded security cooperation with the Gulf is already bearing fruit and pointed to recent joint anti-mining exercises by the navies of 12 countries.

Iran has threatened to target U.S. interests in the Gulf, including military bases, and to block vital oil tanker routes in the Strait of Hormuz if it is attacked.

Plans for a joint missile shield in the Gulf have been on the table for some time, but progress has been slow due to unease among some GCC members about sharing data and where such a system would be commanded.

Individual Gulf states have acquired some advanced defense systems, including the latest versions of the Patriot Air and Missile Defense System. The United Arab Emirates has spent billions of dollars in recent years to protect its cities and oil infrastructure from missile attack.

(Reporting By Andrew Quinn; Editing by David Brunnstrom and Christopher Wilson)

Source: http://news.yahoo.com/u-gulf-countries-seek-advance-missile-defense-plan-213554810--finance.html

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Twitter Not Yet A Mainstream Technology - Business Insider

Twitter is a great product, and millions of people have become addicted to using it for many hours per day (including me).

Investors have also gone bananas over the company, bidding its valuation up higher than $10 billion.

And advertisers have had very encouraging things to say about the power of Twitter as an advertising and customer-service channel.

But given the mind-boggling ubiquity of Twitter awareness--the little bird and @handles and quoted tweets are everywhere--it's easy to lose sight of something.

In the grand scheme, Twitter just isn't that big.

Oh, sure, in terms of sign-ups and monthly web visitors, Twitter is huge. Over 90 million people landed on Twitter.com last month. And the service blew past 500 million global accounts a while ago.

But the little-discussed secret about Twitter is that only a tiny fraction of those who have signed up for accounts on Twitter use it regularly.

And as far as regular usage is concerned, Twitter isn't even close to becoming a mainstream technology.

Don't believe it?

Here's what a recent Pew study found:

About one-in-ten Americans (13%) ever use Twitter or read Twitter messages. By comparison, more than half (54%) ever use other social networking sites, such as Facebook, Google Plus or LinkedIn.

Mainstream technologies and media have 30%-100% penetration, not 10%.

Facebook is a mainstream technology.

Google is a mainstream technology.

Smartphones are a mainstream technology.

Twitter is not a mainstream technology.

What Twitter is is a technology that almost everyone is aware of, thanks to its spectacular marketing and usage by dozens of high-profile celebrities to reach hundreds of millions of fans (here's looking at you, Bieber). But it's also a technology that only a small slice of the population regularly uses.

Now, from the perspective of those who are addicted to Twitter, this is very hard to believe. But the Pew study isn't an isolated freak finding.

For example, most Twitter addicts regard Twitter as the mainstream news medium for the digital age. But this, too, is a warped perception.

Another Pew study, from two years ago, asked Americans "where they got their news yesterday." Only 2% of those surveyed said they got it from Twitter. In this year's study, that percentage had increased only to 3%. Those are tiny numbers, especially for a technology that many people regard as ubiquitous.

Twitter is a great company and a great service, and it has a great mainstream brand.

But the service itself has not yet gone mainstream, at least not in terms of regular usage.

Those who keep arguing (on Twitter) that Twitter will soon vault past Facebook and crush television would do well to remember that.

Source: http://www.businessinsider.com/twitter-not-yet-a-mainstream-technology-2012-9

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Tim Cook apologizes for Maps mess

Well, it's hardly a secret that customers are unhappy with Apple's new mapping solution in iOS 6. And, while the company has admitted that, perhaps, it's not quite up to snuff yet, it has played down Maps' flaws and urged customers to be patient. Today, in an open letter to the Apple faithful, Tim Cook struck a far more candid and conciliatory tone, apologizing for failing to deliver a "world-class" product. Cook went so far as to suggest that unhappy customers could check out offerings from competitors like Bing, MapQuest, Google and Nokia -- at least until Cupertino sorts this mess out. You'll find the complete text of the letter after the break.

Update: As CNET reports, Apple has now also gone one step further and added a new list of featured mapping alternatives to the App Store, including apps from TeleNav, Garmin, Magellan and others.

You can read our editorial on Apple apologies since the launch of the iPhone here.

Continue reading Tim Cook apologizes for Maps mess

Filed under: Cellphones, Software, Mobile, Apple

Tim Cook apologizes for Maps mess originally appeared on Engadget on Fri, 28 Sep 2012 08:55:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2012/09/28/tim-cook-apologizes-for-maps-mess/

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Assange: Obama exploiting Arab Spring in campaign

UNITED NATIONS (AP) ? WikiLeaks founder Julian Assange accused President Barack Obama on Thursday of seeking to exploit the Arab uprisings for personal political gain, as he addressed a sideline meeting of the U.N. General Assembly via videolink from his hideout at a London embassy.

The Australian activist has sheltered inside Ecuador's embassy in London ? beyond the reach of British police ? since June 19, when he sought refuge after he exhausted all legal routes to avoid extradition to Sweden for questioning over sex crimes allegations.

Assange and his supporters claim that the Swedish sex case is part of a Washington-orchestrated plot to make him stand trial in the United States over his work with WikiLeaks, which has published thousands of secret U.S. diplomatic cables and other documents. Both Sweden and the U.S. reject that claim.

At a sideline meeting organized by Ecuador, the activist attempted to draw parallels between himself and the instigators of the Arab Spring ? claiming that they had all been let down by Obama.

"It must come as a surprise to Tunisians for Barack Obama to say the U.S. supported the forces of change in Tunisia," Assange said, speaking from Ecuador's tiny apartment-sized London mission.

He claimed that uprisings across the Arab world had been inspired, in part, by his organization's disclosures about despotic rulers, including Tunisia's deposed President Zine El Abidine Ben Ali.

Assange claimed that Obama ? whose administration he accuses of building a criminal case against WikiLeaks and of harassing its staff ? was seeking to exploit the reforms of the Arab Spring during his reelection campaign.

"Mohamed Bouazizi did not set himself on fire so that Barack Obama could get reelected," Assange told the meeting, referring to the 2011 self-immolation by a Tunisian fruit vendor which sparked the uprising that toppled Ben Ali.

Assange, who made no reference to the Swedish sexual misconduct case as he addressed diplomats, also accused Britain and Sweden of failing to provide guarantees that he would not face extradition to the U.S. to help preserve close military and intelligence links with Washington.

Both European nations insist that Assange must be sent to Sweden under international and European law, and that they cannot legally offer any pledges to refuse a possible future U.S. extradition request.

Ecuador's President Rafael Correa has granted Assange asylum, but if he steps outside the country's London embassy he will be arrested by police who surround the building.

The case has left Britain, Ecuador and Sweden at a diplomatic impasse. Foreign ministers from Quito and London will meet Thursday in New York, as Assange marks 100 days holed up in the embassy.

Ecuador's foreign minister Ricardo Patino told the meeting that he believed there were "many ways to achieve a solution," without specifying potential routes. British Foreign Secretary William Hague said Tuesday that he saw "no sign of any break through" in the saga.

Britain's foreign ministry said it was "committed to seeking a diplomatic solution" with Ecuador, but insisted that it was legally obliged to send Assange to Sweden.

Source: http://news.yahoo.com/assange-obama-exploiting-arab-spring-campaign-005656566.html

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Jerome Horwitz dies at 93; developed potent anti-AIDS drug AZT

Jerome Horwitz, a medical researcher at Wayne State University in Detroit, had spent more than a decade developing a drug he hoped would work against cancer. But the compound failed to help the lab mice he tested it on, so in 1970 he "dumped it on the junk pile," wrote up his disappointing findings and moved on. He didn't bother applying for a patent.

What Horwitz didn't know was that the drug ? AZT ? was destined for success.

Almost 20 years after he had begun his work, scientists at the National Cancer Institute discovered AZT slowed the development of what had been thought to be an untreatable scourge, AIDS. In 1987, AZT became the first drug approved by the Food and Drug Administration for use against the disease caused by the human immunodeficiency virus, HIV.

The drug company that patented and marketed AZT helped establish a chair at Wayne State in Horwitz's name, but the chemist never shared a penny of the billions of dollars made because of his work. As he told the Chronicle of Higher Education many years later, "if I was ever bitter, it's long since passed" because of the millions of lives AZT has saved.

Once described as "one of academe's most under-recognized inventors," Horwitz died Sept. 6 in West Bloomfield Township, Mich. He was 93 and had heart problems, said his wife, Sharon Horwitz.

Horwitz "didn't have a patent, he didn't make money, but there is no question that what he did really dramatically accelerated the development of anti-retroviral drugs," Dr. Paul Volberding, director of the AIDS Research Institute at UC San Francisco, said this week. "It's impossible to be sure, but it would have taken a considerably longer time without his pioneering work."

When AZT made headlines in the 1980s, Horwitz briefly held the spotlight: People magazine named him one of the 25 most intriguing people of 1986 and he appeared on television news shows.

AZT was a controversial therapy because of its harsh side effects and prohibitive price ? about $8,000 a year. It has largely been replaced by less toxic drugs. But Horwitz developed two other drugs that have remained in the anti-AIDS/HIV arsenal, including dideoxycytidine, the second drug approved for AIDS patients, and stauvudine.

Horwitz also created a solution called X-Gal that is widely used to identify proteins.

"I didn't patent it ? story of my life," he told the Chronicle upon his retirement from Wayne State in 2005.

Horwitz was in his 80s when he shared in a five-year, $900,000 grant from the National Cancer Institute to refine drugs capable of treating solid tumors. That work led to Horwitz's first royalty check at 86.

Born in Detroit on Jan. 16, 1919, Horwitz was the son of a businessman who sold poultry. Disinclined to spend his life cleaning up chicken coops, he found his own path early in his teens, when he read "Microbe Hunters" by Paul de Kruif, a 1926 classic about groundbreaking scientists. "A light bulb went on," Horwitz recalled in the Detroit News in 2001. "I knew what I wanted to do."

He graduated with a degree in chemistry from the University of Detroit in 1942, earning a master's there two years later. Barred from World War II service because of high school football injuries, he went on to the University of Michigan and obtained a doctorate in chemistry in 1948.

In 1951, he joined the Illinois Institute of Technology, where he was part of a team developing solid rocket fuels for the Navy. He did not enjoy working with explosive materials, however, and in 1955 returned to Detroit to work at what became the Michigan Cancer Foundation. It is now called the Barbara Ann Karmanos Cancer Institute at Wayne State University.

In addition to his wife, Horwitz is survived by two daughters and five grandchildren.

In 1964, with the war on cancer in full swing, many scientists were randomly pulling drugs off the shelf to test their potential as anti-cancer agents, but Horwitz found this approach intellectually unsatisfying. He wanted to analyze the cancer cells and design a drug that would disrupt their growth.

Knowing that the cells divide using raw materials called nucleosides, he created what he called "fraudulent nucleosides" that were so similar to the real thing the cell would be tricked into using them. The fakes, he theorized, would gum up the cell's replication machinery and halt the development of the tumor.

Horwitz was ahead of his time in his approach, now called "rational drug design." Instead of trial-and-error, rational drug designers create a drug for a specific biological target, such as a cancer cell.

"He was able to take his scientific understanding and say ... 'I am going to devote my life to design a therapy that will strike at the heart of the disease,' " said Wei-Zen Wei, a longtime colleague and associate director at the Karmanos Cancer Institute. "At the time it was risky. He took a chance."

When Horwitz tested AZT, or azidothymidine, on leukemic mice, nothing happened. He admitted defeat and didn't think about it again until the mid-1980s, when scientists were randomly testing drugs in a frantic search for one that would combat AIDS.

At the National Cancer Institute, a group of researchers found the compound curbed the activity of HIV, a strange virus from a family known as retroviruses. Retroviruses were barely known at the time of Horwitz's work on the drug.

Horwitz learned that AZT had come back to life when a colleague pointed out a report on the results published by the researchers in 1985.

"My colleagues and I said that we had a very interesting set of compounds," he told the New York Times in 1986, "that were just waiting for the right disease."

elaine.woo@latimes.com

Source: http://feeds.latimes.com/~r/latimes/news/science/~3/gbct_67fM3I/la-me-adv-jerome-horwitz-20120927,0,2480093.story

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Check out our Creative Writers! | SSAWW Conference 2012 ...

Check out our creative writing panelists. We?re so excited to feature such a talented group. Books will be available for purchase and the authors will be available for signing. Our keynote speaker, Dorothy Allison, will read at 5pm following these two exciting panels!

Highlighting Today?s American Women Writers I

Friday, October 12:30-1:45pm

Maricela DeMirjyn, Ph.D., will chair the panel. She is Assistant Professor of Ethnic Studies at Colorado State University. She is the author of Las Madonnas Morenas: Feminist Narratives of Cultural & Sexual Spirituality. For more information, visit http://ethnicstudies.colostate.edu/people/demirjyn.html

Emma P?rez, Ph.D., is Chair and Professor of Ethnic Studies at the University of Colorado-Boulder. She is the author of two novels Gulf Dreams and Forgetting the Alamo, or, Blood Memory, as well as the monograph The Decolonial Imaginary: Writing Chicanas into History. For more information, visit http://ethnicstudies.colorado.edu/faculty/perez/

Joy Castro, Ph.D., is Associate Professor of English and Ethnic Studies at the University of Nebraska-Lincoln. She is the author of two memoirs, The Truth Book and Island of Bones, as well as the forthcoming novel Hell or High Water. For more information, visit http://www.joycastro.com/Bio.htm and http://www.amazon.com/Joy-Castro/e/B001K8PFUG

Lily Hoang, is Assistant Professor of English, teaching Fiction in the MFA program at New Mexico State University. She is the author of Changing, Parabola, Unfinished, and The Evolutionary Revolutionary. For more information, visit http://www.nmsu.edu/~english/mfa/faculty_lily.php and http://www.amazon.com/s?ie=UTF8&keywords=lily%20hoang&rh=i%3Aaps%2Ck%3Alily%20hoang&page=1

Highlighting Today?s American Women Writers II

Friday, October 12, 2:00-3:15pm

Sasha Steensen is Professor of English at Colorado State University. She is the author of correspondence (with Gordon Hadfield), The Future of an Allusion, A History of the Human Family, A Magic Book, and The Method. Steensen plans to read from Sentences and Waters: A Lenten Poem. For more information, please visit http://central.colostate.edu/people/steensen/ andhttp://www.amazon.com/gp/search/ref=sr_tc_2_0?rh=i%3Astripbooks%2Ck%3ASasha+Steensen&keywords=Sasha+Steensen&ie=UTF8&qid=1339120028&sr=1-2-ent&field-contributor_id=B001K8W518

Julie Carr is Assistant Professor of English at the University of Colorado-Boulder. She is the author of Mead: An Epithalamion, Equivocal, 100 Notes on Violence, and Sarah-Of Fragments and Lines. Carr will read from her poems ?Real Life? and ?Rag.? For more information, please visit http://english.colorado.edu/blog/2010/07/28/carr-julie/ and http://www.amazon.com/s/ref=nb_sb_noss_1?url=search-alias%3Daps&field-keywords=julie+carr

Michelle Naka Pierce is Associate Professor and Director of the Jack Kerouac School of Disembodied Poetics at Naropa University. She is the author of Continuous Frieze Bordering Red; She, A Blueprint (with artwork by Sue Hammond West); Beloved Integer; and Tri/Via (with Veronica Corpuz). Pierce will be reading from Continuous Frieze Bordering Red. For more information, please visit http://naropa.edu/nwc/faculty.cfm and http://www.amazon.com/s/ref=sr_tc_2_0?rh=i%3Astripbooks%2Ck%3AMichelle+Naka+Pierce&keywords=Michelle+Naka+Pierce&ie=UTF8&qid=1339121048&sr=1-2-ent&field-contributor_id=B001K8SD82.

Keynote Speaker

Friday, October 12, 5:00-6:30pm

Dorothy Allison is the critically and popularly acclaimed author of the award-winning short-story collection, Trash (1989, expanded in 2002); a collection of poems, The Women Who Hate Me (1991); the novel Bastard Out of Carolina (1992), which was a finalist for the National Book Award; a collection of essays, Skin: Talking about Sex, Class and Literature (1995); a memoir, Two or Three Things I Know for Sure (1996); a second novel, Cavedweller (1999); and the forthcoming novel, She Who.

In 2007, Allison received the Robert Penn Warren Award for Fiction. She has also held several positions as writer-in-residence and/or Visiting Professor at universities across the U.S. According to Allison?s website, ?she describes herself as a feminist, a working class storyteller, a Southern expatriate, a sometime poet and a happily born-again Californian.? Born in Greenville, South Carolina, Allison currently resides in Northern California with her partner and son.
Allison will speak at this year?s conference on Friday, October 12, from 5:00-6:30. Several of her works will be available for purchase, and she will do a signing after her talk.

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Source: http://ssaww2012.wordpress.com/2012/09/26/check-out-our-creative-writers/

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Tigers beat Royals on Peralta's groundout in 8th

Detroit Tigers' Andy Dirks makes Kansas City Royals second baseman Irving Falu jump after tagging second base on a Detroit Tigers' Jhonny Peralta fielder's choice in the eighth inning of a baseball game in Detroit, Wednesday, Sept. 26, 2012. Peralta was safe at first base and pinch runner Don Kelly scored on the play. (AP Photo/Paul Sancya)

Detroit Tigers' Andy Dirks makes Kansas City Royals second baseman Irving Falu jump after tagging second base on a Detroit Tigers' Jhonny Peralta fielder's choice in the eighth inning of a baseball game in Detroit, Wednesday, Sept. 26, 2012. Peralta was safe at first base and pinch runner Don Kelly scored on the play. (AP Photo/Paul Sancya)

Kansas City Royals starting pitcher Jeremy Guthrie, right, walks back to the mound after giving up a solo home run to Detroit Tigers' Austin Jackson, left, in the fourth inning of a baseball game in Detroit, Wednesday, Sept. 26, 2012. (AP Photo/Paul Sancya)

Kansas City Royals second baseman Irving Falu throws to first base for an out on a ground ball from Detroit Tigers' Omar Infante in the second inning of a baseball game in Detroit, Wednesday, Sept. 26, 2012. (AP Photo/Paul Sancya)

Kansas City Royals left fielder Alex Gordon dives safely into home plate to score on an RBI single by Billy Butler as Detroit Tigers catcher Alex Avila waits for the throw in the third inning of a baseball game in Detroit, Wednesday, Sept. 26, 2012. (AP Photo/Paul Sancya)

Detroit Tigers starting pitcher Rick Porcello throws against the Kansas City Royals in the first inning of a baseball game in Detroit, Wednesday, Sept. 26, 2012. (AP Photo/Paul Sancya)

DETROIT (AP) ? Most of the 32,360 fans at Comerica Park groaned when Jhonny Peralta hit a tailor-made double-play grounder that looked set to end the eighth inning.

Andy Dirks made them cheer.

Jhonny Peralta's grounder brought home the go-ahead run because Dirks' hard slide broke up a potential inning-ending double play in the eighth and the Detroit Tigers beat the Kansas City Royals 5-4 Wednesday night.

"I was just trying to break up the double play and try to get a piece of him any way I could to help us score that run," Dirks said. "That's just kind of the way you play baseball."

Detroit wound up alone in first place for the first time since before play on July 24 when the White Sox lost to Cleveland later.

Triple Crown candidate Miguel Cabrera was robbed of a tiebreaking homer in the fifth inning by Alex Gordon's catch above the left-field wall.

Detroit found a way to break through the eighth.

It appeared as if Kansas City was going to keep the score tied when Peralta hit a grounder to third baseman Mike Moustakas. Dirks, though, slid so late and hard that second baseman Irving Falu didn't attempt a throw, allowing pinch-runner Don Kelly to score what he said was most important run of his career.

"Peralta was slow getting out of the box, so that's an easy double play," Moustakas said. "I'm always going to go to second on that play, but Dirks did a heck of a job to break it up."

Dirks was swarmed by teammates in the dugout to celebrate the gritty, clean play he made.

"That's good, old-fashioned baseball," Tigers manager Jim Leyland said.

Delmon Young hit an infield single with one out in the eighth off Kelvin Herrera (4-3) and was replaced by Kelly, who stole second base and took third on Dirks' single.

Detroit's Alex Avila hit a two-run homer and Austin Jackson had a solo shot in the fourth inning to tie the game.

Cabrera, who went 0 for 4, started the day with the AL lead in batting average and RBIs and was one homer behind Texas' Josh Hamilton. Baseball hasn't had a player lead a league in all three categories since Boston's Carl Yastrzemski in 1967.

Cabrera was close to pulling into at least a temporary tie with Hamilton for homers, but Gordon prevented him from hitting his 43rd homer.

"It was hit so high that I had plenty of time to find the fence and get ready," Gordon said. "I thought I might have to climb the wall or at least jump, but at the end, I just had to put my glove up."

The Tigers have won six of nine games on their final 10-game homestand and 32 of their last 43 games at Comerica Park. They had, however, lost 11 straight one-run games since beating Toronto 3-2 on Aug. 23.

Kansas City has lost four straight ? three consecutive against Detroit ? after winning four in a row, including two against the White Sox.

"I love my team," Royals manager Ned Yost said. "We've played three games here, and we're 0-3, but we're in these games and we're not far from the point where we are going to be consistently winning these teams.

"No matter what has happened this year, we've gotten knocked down and gotten right back up. These guys fight every day, and they are going to do everything in their power to beat Detroit in these games."

Detroit starter Rick Porcello lasted just four innings, giving up four runs and seven hits.

"His velocity dropped and that was a red flag for me," Leyland said.

Luis Marte got two outs in the fifth and Al Alburquerque gave up only one hit over 2 1-3 innings. Joaquin Benoit (4-3) allowed one hit in the eighth. Jose Valverde closed the game for his 32nd save in 37 chances.

Royals starter Jeremy Guthrie allowed four runs on seven hits and two walks over seven innings.

Young doubled and Dirks singled to give the Tigers a 1-0 lead in the second.

Kansas City went ahead 3-1 in the third inning after Falu, David Lough and Billy Butler doubled. Jeff Francoeur's solo homer in the fourth inning gave the Royals a three-run lead.

NOTES: Detroit is sending Doug Fister (10-9) to the mound in its final scheduled home game Thursday afternoon against Kansas City and Luis Mendoza (8-9) before the Tigers close the regular season on the road against Minnesota and the Royals. ... Guthrie was 4-0 with a 1.75 ERA in his previous nine starts all of which were Kansas City wins. ... Porcello, who hadn't pitched since Sept. 16 because a rainout led to his previous scheduled start getting skipped, is 0-6 in his last eight outings. ... Yastrzemski told reporters in Boston on Wednesday that playing meaningful games down the stretch with help Cabrera's attempt to win the Triple Crown. "One thing that's going to help him is he's in a pennant race," Yastrzemski said. ... Falu matched a career high with three hits.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2012-09-27-Royals-Tigers/id-6c5b46fd58f94b71b29cd8bf509256ce

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Poster advertising neo-Nazi music festival in Idaho places police on alert

BOISE, Idaho - The Boise mayor's office is fielding numerous complaints about a neo-Nazi music festival planned for early October, the city's police department said.

Authorities have been on alert since advertisements for Hammerfest 2012 near Boise surfaced online, said Sgt. Jeff Basterrechea, who is with the police department's gang intelligence unit. The white supremacist group Hammerskin Nation plans to hold the event Oct. 6, according to the flier circulating online.

"This is a very high priority," Basterrechea said. "The mayor's office has received numerous complaints about this."

The skinhead group is rooted in Texas and has branches in Australia and Canada, according to the SITE Monitoring Service, a private intelligence firm that searches the Internet for extremist activity. The gunman who killed six worshippers at a Sikh temple in Wisconsin last month described himself as a member.

The group has not disclosed the exact location of the planned Idaho event and attempts to contact local Hammerskin chapters were unsuccessful, KTVB-TV reported. Police are working with local venues to make them aware of the group, Basterrechea said.

Former neo-Nazi skinhead Marine T.J. Leyden told the news station he previously recruited for the group with events like Hammerfest. Leyden, who famously left the movement in 1996 and has promoted tolerance ever since, said the Boise event will be used to boost the group's numbers.

"They're going to say, 'Hey, come to this show.' These kids are going to see it, they're going to get all pumped up, they're going to think it's fantastic," said Leyden, who cautioned that protesters should stay away and allow law enforcement to monitor the event.

"The group is extremely violent. The Hammerfests that they throw in different parts of the country are designed for a couple things. One it's designed for unity, but it's also designed to get people's anxiety up," Leyden said.

"My best suggestion is let law enforcement handle these guys. Don't go out and counter-protest. This is what they want. They want counter-protesters yelling, screaming and hollering out there to make them feel like they're big, tough men."

In 2009, the Homeland Security Department issued several reports on individual foreign and domestic extremist groups such as al-Qaida and Hammerskin Nation. The Hammerskin assessment said many of the group's members received military training and fought in Iraq and Afghanistan.

Source: http://news.yahoo.com/poster-advertising-neo-nazi-music-festival-idaho-places-185818405.html

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Notre Dame exercises 3-year out in Michigan deal

ANN ARBOR, Mich. (AP) ? Notre Dame is opting out of its series with Michigan, meaning the last scheduled game between college football's winningest programs will take place in 2014.

A letter from Notre Dame athletic director Jack Swarbrick to Michigan athletic director Dave Brandon cancelling games in 2015-2017 was obtained by The Associated Press on Tuesday through a Freedom of Information Act request.

Brandon told the AP he was handed the letter on the field in South Bend, Ind., about an hour before Saturday night's game.

"I put the letter in my pocket and didn't bother to read it right away because I was focused on the game we were about to play," Brandon said. "I read it on the way home Sunday morning."

The Fighting Irish recently decided to move to the Atlantic Coast Conference in every sport except football and hockey, though the football team will play five games a year against league opponents, starting no later than 2015.

"While this move is a necessary precaution as we begin the process of meeting our new scheduling commitment to the ACC," Swarbrick wrote in his letter to Brandon, "please know that Notre Dame very much values its relationship with Michigan and we look forward to working with you to ensure that our great football rivalry can continue."

Brandon said he hopes to work with Swarbrick on another contract to extend the series.

"The ball is in their court because they've triggered the three-game notice," he said. "We'll play them next year at Michigan Stadium for the last time in a while ? it appears ? and we'll make our last scheduled trip to South Bend in 2014. There will likely be nothing on the board for five years after that. Beyond that, I don't know what will happen."

The Irish beat the Wolverines 13-6 over the weekend in the latest game of a storied series that dates to 1887. They've played every year since 2002 and regularly since 1978 after not meeting from 1944-77 or 1910-41. Michigan and Notre Dame were scheduled to take a hiatus during the 2018-19 seasons.

Swarbrick's letter is dated a day before the schools met on the field and cites last year's agreement.

"Because I am providing you with this notice prior to the commencement of this year's football game on September, 22, 2012," Swarbrick wrote, "there is no liability to Notre Dame for cancelling those games."

The contract has an automatic rollover provision with a year being added each time a game is played, according to Notre Dame senior associate athletics director John Heisler.

"We needed to avoid the automatic addition of additional games until we can get a better understanding of our available inventory in those years," Heisler said in a released statement, "an understanding that will develop as we implement our five-game scheduling commitment to the Atlantic Coast Conference."

By opting out of the contract now, the Irish wind up as the host for two of the final three years of the deal ? and will avoid playing at the Big House twice during the final three years.

Wolverines coach Brady Hoke said Notre Dame has to do what is best for itself, and must've determined that was to get out of the rivalry.

"Obviously we kind of enjoy and cherish the rivalry," Hoke said Tuesday night. "There's so much history there."

No. 10 Notre Dame (4-0) is in the top 10 for the first time since 2006. Michigan (2-2) started the season No. 8 and has dropped out of the poll after losses to No. 1 Alabama and then the Irish. Both teams have a bye this week.

The Wolverines have an NCAA-best .735 winning percentage in football and the Irish (.732) are second. Michigan leads all-time series 23-16-1.

"Michigan has always enjoyed and respected our national rivalry with Notre Dame," Brandon said. "We understand there have been periods of times that we've had a hiatus to take a couple years off to play other teams and that was something we expected along the way.

"It's unfortunate that it would appear we're going to go a substantial amount of time between games. But that is a decision Notre Dame has made. Our job is to find opponents that are exciting for our student-athletes as well as our fans to replace Notre Dame."

Michigan State expects its long series with Notre Dame to continue with matchups in four straight seasons followed by two-year breaks through the 2031 season. If the Irish, or the Spartans, want to get out of the deal they can pay the other school as little as $150,000 with a two-year notice. Michigan State athletic director Mark Hollis said earlier this month that he doesn't expect Notre Dame's ACC affiliation to affect the rivalry.

___

Follow Larry Lage on Twitter: http://twitter.com/larrylage

Source: http://news.yahoo.com/notre-dame-exercises-3-michigan-deal-155025044--spt.html

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Language use is simpler than previously thought, study suggests

ScienceDaily (Sep. 25, 2012) ? For more than 50 years, language scientists have assumed that sentence structure is fundamentally hierarchical, made up of small parts in turn made of smaller parts, like Russian nesting dolls.

A new Cornell study suggests language use is simpler than they had thought.

Co-author Morten Christiansen, Cornell professor of psychology and co-director of the Cornell Cognitive Science Program, and his colleagues say that language is actually based on simpler sequential structures, like clusters of beads on a string.

"What we're suggesting is that the language system deals with words by grouping them into little clumps that are then associated with meaning," he said.

Sentences are made up of such word clumps, or "constructions," that are understood when arranged in a particular order. For example, the word sequence "bread and butter" might be represented as a construction, whereas the reverse sequence of words ("butter and bread") would likely not.

The sequence concept has simplicity on its side; language is naturally sequential, given the temporal cues that help us understand and be understood as we use language. Moreover, the hierarchy concept doesn't take into account the many other cues that help convey meaning, such as the setting and knowing what was said before and the speaker's intention.

The researchers drew on evidence in language-related fields from psycholinguistics to cognitive neuroscience. For example, research in evolutionary biology indicates that humans acquired language (and animals did not) because we have evolved abilities in a number of areas, such as being able to correctly guess others' intentions and learn a large number of sounds that we then relate to meaning to create words. In contrast, the hierarchy concept suggests humans have language thanks only to highly specialized "hardware" in the brain, which neuroscientists have yet to find.

Research in cognitive neuroscience shows that the same set of brain regions seem to be involved in both sequential learning and language, suggesting that language is processed sequentially. And several recent psycholinguistic studies have shown that how well adults and children perform on a sequence learning task strongly predicts how well they can process the deluge of words that come at us in rapid succession when we're listening to someone speak. "The better you are at dealing with sequences, the easier it is for you to comprehend language," Christiansen said.

The study by Christiansen and his colleagues has important implications for several language-related fields. From an evolutionary perspective, it could help close what has been seen as a large gap between the communications systems of humans and other nonhuman primates. "This research allows us a better understanding of our place in nature, in that we can tie our language ability, our communication abilities, more closely to what we can see in other species. It could have a big impact in terms of allowing us to think in more humble terms about the origin of language in humans," Christiansen said.

The research could also affect natural language processing, the area of computer science that deals with human language, by encouraging scholars to focus on sequential structure when trying to create humanlike speech and other types of language processing, Christiansen said. He pointed out that machines already successfully perform such tasks as translation and speech recognition thanks to algorithms based on sequential structures.

The study, "How hierarchical is language use?" was published Sept. 12 in the Proceedings of the Royal Society B: Biological Sciences. The research was funded by the European Union, the Netherlands Organization for Scientific Research and the Binational Science Foundation.

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The above story is reprinted from materials provided by Cornell University. The original article was written by Susan Kelley.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. S. L. Frank, R. Bod, M. H. Christiansen. How hierarchical is language use? Proceedings of the Royal Society B: Biological Sciences, 2012; DOI: 10.1098/rspb.2012.1741

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/living_well/~3/ELHMnBWHm7s/120925143555.htm

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Transforming Coffee Table Seats an Entire Dinner Party Worth of Guests [Design]

You'll never have to break out the TV trays or ask your dinner guests to dine off their laps with Ozzio's beautiful transforming coffee table. One moment it's sitting low to the ground making it the perfect accessory for your living room set. And the next a gas lifting device brings it up to dining height while an expanding surface provides enough capacity for what looks to be at least ten guests. More »

Source: http://feeds.gawker.com/~r/gizmodo/full/~3/b1kGZC8EZb8/transforming-coffee-table-seats-an-entire-dinner-party-worth-of-guests

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Microfluidic device: Hundreds of biochemical analyses on a single chip

ScienceDaily (Sep. 24, 2012) ? Scientists at Ecole Polytechnique F?d?rale de Lausanne and the University of Geneva have developed a microfluidic device smaller than a domino that can simultaneously measure up to 768 biomolecular interactions.

Inside our cells, molecules are constantly binding and separating from one another. It's this game of constant flux that drives gene expression asides essentially every other biological process.

Understanding the specific details of how these interactions take place is thus crucial to our overall understanding of the fundamental mechanisms of living organisms. There are millions of possible combinations of molecules, however; determining all of them would be a Herculean task. Various tools have been developed to measure the degree of affinity between a strand of DNA and its transcription factor. They provide an indication of the strength of the affinity between them.

"Commercial" devices, however, have one main drawback: many preliminary manipulations are necessary before an experiment can be carried out, and even then, the experiment can only focus on a dozen interactions at a time.

Microns-wide channels

As part of his doctoral research at the California Institute of Technology (Caltech), Sebastian Maerkl designed a device that he named "MITOMI" -- a small device containing hundreds of microfluidic channels equipped with pneumatic valves. This week Maerkl, who is now an assistant professor in EPFL's Bioengineering Institute, is publishing an article describing the next step in the evolution of the device in Proceedings of the National Academy of Sciences (PNAS). The new version, "k-MITOMI," was developed in the context of the SystemsX.ch RTD DynamiX in cooperation with the University of Geneva.

This microfluidic device has 768 chambers, each one with a valve that allows DNA and transcription factors to interact in a very carefully controlled manner. "In traditional methods, we generally manage to determine if an interaction takes place or not, and then we restart the experiment with another gene or another transcription factor," Maerkl explains. "Our device goes much further, because it allows us to measure the affinity and kinetics of the interaction."

The strength of the device lies in a sort of "push-button" in its microreactors. A protein substrate is immobilized on the device; above it circulates a solution containing DNA moelcules. The push-button is activated at regular intervals of a few milliseconds, trapping protein-DNA complexes that form on the surface of the device. "Then we close the lid, and fluorescence reveals the exact number of bound molecules," explains Maerkl. "We can also observe how long these molecules remain bound."

In addition to providing quantitative kinetic information, the k-MITOMI device can work in a "massively parallel" manner. Each of the 768 independent chambers can simultaneously analyze different molecule pairs. It can also be used to synthesize proteins in vitro, with a massive reduction in time and number of manipulations compared to the traditional method, which involves producing proteins inside a living organism such as a bacterium, purifying, and putting them in contact with the genes to be studied.

"The number of protein-protein and protein-DNA interactions that remain to be characterized is phenomenal. Our device not only allows us to accelerate the acquisition of this information, which is crucial to our understanding of living organisms, but it also meets a need for the production of specific proteins," adds Maerkl.

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Story Source:

The above story is reprinted from materials provided by Ecole Polytechnique F?d?rale de Lausanne.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. M. Geertz, D. Shore, S. J. Maerkl. Massively parallel measurements of molecular interaction kinetics on a microfluidic platform. Proceedings of the National Academy of Sciences, 2012; DOI: 10.1073/pnas.1206011109

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/tk2Dq0mNSwQ/120925091830.htm

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Rangers rally past A's 5-4 for 5-game AL West lead

ARLINGTON, Texas (AP) ? Adrian Beltre singled home the winning run in the ninth inning and the Texas Rangers rallied past Oakland 5-4 on Monday night to stretch their AL West lead over the Athletics to five games with nine to play.

Beltre, whose 35th homer tied the score in the seventh, grounded a sharp single through the middle of the infield off Tyson Ross (2-11) in the ninth, bringing home pinch-runner Craig Gentry to end the opener of a four-game series.

The Rangers got the inning started with consecutive singles by Mitch Moreland and Ian Kinsler before Elvis Andrus' sacrifice bunt. Josh Hamilton, who had already hit his major league-best 43rd homer after missing the previous five games with a cornea issue, was intentionally walked to load the bases for Beltre.

Joe Nathan (3-4), the sixth Rangers pitcher, struck out two in the ninth. That included a strikeout of Seth Smith as Stephen Drew was caught stealing to end the inning.

It was the first of seven meetings in the last 10 days of the regular season between the two-time defending American League champion Rangers and A's, who have lost six of seven after winning 17 of their previous 21 games.

Oakland has a two-game lead over the idle Los Angeles Angels for the second AL wild card.

Beltre hit a two-run homer with two outs in the seventh to tie the game at 4, a shot that came with Hamilton on base.

A's rookie right-hander Dan Straily struck out eight and left with a 4-2 lead after 6 2-3 innings with Hamilton due to bat and the bases empty.

Dean Blevins walked Hamilton, the only batter he faced, before Pat Neshek gave up the two-run drive to Beltre.

It was Neshek who allowed Raul Ibanez's tying, two-run homer to cap a four-run 13th inning Saturday by the AL East-leading New York Yankees, who then won on a two-out error in the 14th ? a game that Ross also lost.

Hamilton hit a 441-foot solo homer in the fifth that landed in the second deck of seats high above the Rangers' bullpen in right-center to get Texas within 3-2.

Josh Donaldson and Yoenis Cespedes homered for Oakland, and Cliff Pennington had an RBI single in the sixth.

Donaldson lined a two-run shot deep into the left-field seats in the second off Derek Holland. Cespedes hit a two-out solo homer, his 21st, for a 3-1 lead an inning later.

Holland pitched only three innings, his shortest outing since May 30 when the left-hander gave up eight runs over 1 2-3 innings in the Rangers' 21-8 home loss to Seattle.

The Rangers got an unearned run in the second when Michael Young was hit by a pitch before Donaldson's error at third base. Young scored on Moreland's bloop single that ended a string of 24 consecutive at-bats by the Rangers with runners in scoring position without a hit.

Hamilton's homer was followed by consecutive doubles by Beltre and Nelson Cruz that failed to produce a run. Beltre was picked off second after wandering too far off the base on a pitch in the dirt that catcher Derek Norris quickly recovered.

NOTES: CF Coco Crisp was out of the A's starting lineup for the sixth game in a row because of an infection in both eyes. Manager Bob Melvin said Crisp has seen three doctors but his condition hasn't improved much. ... Holland is 6-0 in 10 September starts the past two seasons. ... After giving up three consecutive extra-base hits in the fifth, Straily retired the last six batters he faced.

Source: http://news.yahoo.com/rangers-rally-past-5-4-5-game-al-033549863--mlb.html

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Ref Rage: Seahawks stun Pack on final play, 14-12

SEATTLE (AP) ? Just when the anger and complaints from a weekend of contempt toward replacement officials couldn't get any hotter, a disputed call trumps it all.

Replacement ref rage peaked Monday night thanks to Seattle's Golden Tate, and a bizarre touchdown call that will be debated, questioned and re-ignite frustrations over the locked-out officials.

Tate pushed a Green Bay defender out of the way, wrestled another for the ball and was awarded a touchdown on the final play to give the Seahawks a 14-12 victory over the Packers.

The game wasn't over for another 10 minutes after both teams went to their locker rooms and were summoned back to the field for the extra point. But that was just the cap to one of the most bizarre finishes in recent memory.

"Don't ask me a question about the officials," Green Bay coach Mike McCarthy said. "I've never seen anything like that in all my years in football."

"I know it's been a wild weekend in the NFL and I guess we're part of it now," he said.

Russell Wilson threw the 24-yard touchdown pass and the crew of replacement officials agreed Tate caught the pass.

Wilson scrambled from the pocket and threw to the corner of the end zone as the clock expired. Tate shoved Green Bay's Sam Shields out of the way then wrestled with M.D. Jennings for possession. It was ruled on the field as a touchdown and after a lengthy review, referee Wayne Elliott came out from under the hood and announced "the ruling on the field stands" before the crowd at CenturyLink Field erupted in celebration.

"We both had possession of it. I don't even know the rule but I guess the tie goes to the receiver," Tate said.

Asked later if he got his hands on Wilson's pass first, Tate wasn't so sure.

"I think so. ... Oh, well, maybe he did. But I took it from him," Tate said.

Elliott told a pool reporter after the game that the play was ruled as simultaneous possession that was confirmed by the replay official.

"They both possessed it," Elliott said.

The Packers were far from convinced that Tate had possession. Jennings said he had the ball pinned to his chest the entire time. A handful of Packers players began venting on their Twitter accounts right after the game, posting protest messages to their followers ? many of them too profane to print. Offensive lineman T.J. Lang even challenged the NFL to "fine me and use the money to pay the regular refs."

Others took to Twitter to speak their minds.

Hall of Fame quarterback Troy Aikman tweeted "These games are a joke," while NBA MVP LeBron James tweeted "I simply just LOVE the NFL to much to see these mistakes. I'm sick like I just played for the Packers."

Wisconsin State Senator Jon Erpenbach even tweeted NFL Commissioner Roger Goodell's office phone number, saying in a separate tweet that if the ending Monday did not spark an end to the lockout "this season will be a joke."

"Just watching in the back room, I think if you asked Golden Tate to take a lie detector test and ask him did he catch that ball or did M.D. catch that ball, M.D. caught that," Packers wide receiver Greg Jennings said. "It was clear as day ... at least that is what my eyes saw."

Seattle instantly celebrated while the Packers argued with anyone in a striped shirt. Both teams were eventually shoved to the sidelines as Tate stomped through the end zone in celebration. Following the review, Elliott's announcement sent the stadium into delirium and even more confusion ensued until the teams finally returned to the field for the extra point.

"From what I understood from the officials it was a simultaneous catch. Tie goes to the runner. Good call," Seattle coach Pete Carroll said.

Green Bay should not have found itself in the position of watching Wilson's final heave be open for debate.

The Packers shook off a disastrous first half in which Aaron Rodgers was sacked eight times and completely controlled possession in the final 30 minutes. Green Bay ran 41 offensive plays in the second half, got field goals of 29 and 40 yards from Mason Crosby and Cedric Benson's 1-yard TD run with 8:44 left to take a 12-7 lead.

Rodgers finished 26 of 39 for 223 yards and no turnovers. He had quite a different opinion of the disputed catch.

"It was awful. Just look at the replay. And then the fact that it was reviewed, it was awful," he said. "That's all I'm going to say about it.

"We shouldn't have been in that position."

It was Tate's second touchdown of the game after his 41-yard catch in the second quarter gave Seattle a 7-0 lead. He finished with three catches for 68 yards, while Wilson was 10 of 21 for 130 yards.

Green Bay averted disaster when Cedric Benson fumbled on the first play after Seattle missed on a fourth-down pass attempt from the Packers' 7 with 2 minutes remaining. Center Jeff Saturday recovered the fumble, but the Seahawks held and forced a punt from the 4 with 57 seconds left. The 41-yard punt set Seattle up at the Green Bay 46 with 46 seconds remaining.

Wilson hit Sidney Rice for 22 yards on a slant then went for Tate in the end zone, but the ball was batted away with 18 seconds left. He threw over the head of Evan Moore on second down, leaving 12 seconds on the clock, and missed Tate again at the 5.

Wilson took the final snap with 8 seconds remaining. He appeared to be looking for Rice on the right side of the end zone, but rolled left and threw for Tate, who was in a crowd of three defenders. His shove of Shields was obvious and it was never clear in real-time who had possession between Tate and Jennings.

"I was just trying to keep possession of the ball. The guy who was fighting me for it, he's strong. I was just trying to hold onto it until our guys pulled them off of me," Tate said. "I didn't know if they called touchdown, interception, incompletion . I didn't know what was going on. Couldn't hear anything and I just tried to keep fighting for the ball."

Notes: Seattle rookie DE Bruce Irvin had two of Seattle's eight sacks on Rodgers in the first half. Chris Clemons led the way with four sacks, tying an NFL record for most in the first half of any game. ... Benson finished with 45 yards rushing after having just 4 yards at halftime. ... Seattle RB Marshawn Lynch just missed his seventh straight 100-yard rushing game at home with 98 yards on 25 carries. ... Green Bay finished with a 7-minute advantage in time of possession after the teams each had 15 minutes of possession in the first half.

___

Online: http://pro32.ap.org/poll and http://twitter.com/AP_NFL

Source: http://news.yahoo.com/ref-rage-seahawks-stun-pack-final-play-14-081819201--spt.html

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Exposing cancer's lethal couriers

ScienceDaily (Sep. 24, 2012) ? Malignant cells that leave a primary tumor, travel the bloodstream and grow out of control in new locations cause the vast majority of cancer deaths. New nanotechnology developed at Case Western Reserve University detects these metastases in mouse models of breast cancer far earlier than current methods, a step toward earlier, life-saving diagnosis and treatment.

A team of scientists, engineers and students across five disciplines built nanochains that home in on metastases before they've grown into new tissues, and, through magnetic resonance imaging, detect their locations.

Images of the precise location and extent of metastases could be used to guide surgery or ablation, or the same technology used to find the cancer could be used to deliver cancer-killing drugs directly to the cells before a tumor forms, the researchers suggest.

The work is described in this week's online issue of the American Chemical Society journal ACS Nano.

"Micrometastases can't be seen with the naked eye, but you have to catch them at this stage -- see the exact spots they're located and see them all," said Efstathios Karathanasis, assistant professor of biomedical engineering and radiology, and senior author. "Even if you miss only one, you prolong survival, but one metastasis can still kill."

Karathanasis worked with research associate Pubudu M. Peiris, graduate student Randall Toy; undergraduate students Elizabeth Doolittle, Jenna Pansky, Aaron Abramowski, Morgan Tam, Peter Vicente, Emily Tran, Elliott Hayden and Andrew Camann; medical student Zachary Berman, senior research associate Bernadette O. Erokwu, biomedical engineering professor David Wilson, chemical engineering associate professor Harihara Baskaran; and, from the Case Western Reserve School of Medicine, radiology assistant professor Chris A. Flask and pharmacology associate professor and department vice chair Ruth A. Keri.

Tumor detection technologies fail to uncover cancer cells that have taken hold in new locations because young metastases don't behave the same as established tumors.

After a breast cancer cell enters the bloodstream, it most often stops in the liver, spleen or lungs and begins overexpressing surface molecules called integrins. Integrins act as a glue between the cancer cell and the lining of a blood vessel that feeds the organ.

"We target integrins," Karathanasis said. "Normal blood vessel walls don't present integrins towards the blood site unless cancer cells attach there."

To home in on the cancer marker, the researchers first needed to build a nano device that would drift out of the central flow of the blood stream and to the blood vessel walls. The most common shape of nanoparticles is a sphere, but a sphere tends to go with the flow.

Karathanasis' team tailored nanoparticles to connect one to another much like a stack of Legos. Due to its size and shape, the oblong chain tumbles out of the main current and skirts along vessel walls.

The exterior of the chain has multiple sites designed to bind with integrins. Once one site latches on, others grab hold. Compared to nanospheres, the chains' attachment rate in flow tests was nearly 10-fold higher.

To enable a doctor to see where a relative few cancer cells sit in a sea of healthy cells, the scientists incorporated fluorescent markers and, to make the nanochains more visible in magnetic resonance imaging, four links made of iron oxide.

Next, the team tested the chains in a mouse model of an aggressive form of breast cancer that metastasizes to sites and organs much the same way it does in humans.

From established research, they knew metastases would be present five weeks into the modeling. They injected nanochains into the bloodstream and, within an hour, two imaging techniques -- fluorescence molecular tomography and MRI's -- showed where traveling cancer cells had established footholds, primarily in the liver, lungs and spleen.

The metastases located using the nanochains ranged from .2 to 2 millimeters across.

Later imaging at high magnification showed that these metastatic cancer cells were found mostly in the blood vessel walls, before they'd had time to grow into organ tissue.

"Once metastatic cells move into the tissue, develop their own microenvironment, and grow into a 1-centimeter lesion, it typically indicates a late stage of metastatic disease which has an unfavorable outcome," Karathanasis said.

According to the American Cancer Society, the 5-year survival rate of breast cancer patients sharply decreases from 98 percent in cases that catch the disease when it has produced only a localized primary lesion to 23 percent in cases in which distant large metastases have grown.

Now that they've proved the concept works, the team is bringing clinical radiologists on board led by Vikas Gulani, assistant professor of radiology. Their job is to help with a new study, calculating how much new cancer the technology finds and misses.

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Story Source:

The above story is reprinted from materials provided by Case Western Reserve University, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Pubudu M. Peiris, Randall Toy, Elizabeth Doolittle, Jenna Pansky, Aaron Abramowski, Morgan Tam, Peter Vicente, Emily Tran, Elliott Hayden, Andrew Camann, Aaron Mayer, Bernadette O. Erokwu, Zachary Berman, David Wilson, Harihara Baskaran, Chris A. Flask, Ruth A. Keri, Efstathios Karathanasis. Imaging Metastasis Using an Integrin-Targeting Chain-Shaped Nanoparticle. ACS Nano, 2012; : 120924135147007 DOI: 10.1021/nn303833p

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/R1R2wPLlBI8/120924152541.htm

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